A, IGF-1Ea mRNA (muscle); time effect (P < 0.05) and group interaction (P < 0.05). B, IGF-1Ec mRNA (muscle); time effect (P < 0.05) and group interaction (P < 0.05). C, COL1A1 mRNA (muscle); time effect (P < 0.05) and group interaction (P < 0.05). D, COL3A1 mRNA (muscle); time effect (P < 0.05) and group interaction, (P < 0.05). *Time effect, P < 0.05, compared with baseline. $Group effect, P < 0.05, GH vs. Plc within time point. Data are geometric means ± SEM.