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AceCS1 and AceCS2 have different subcellular distributions. AceCS1 is localized in the cell cytoplasm where it generates acetyl CoA for lipid synthesis and cytoplasmic protein acetylation reactions. AceCS1 is also localized in cell nuclei where it generates acetyl CoA for histone and other protein acetylation reactions. AceCS2 is localized in mitochondria where it supplies acetyl CoA for energy derivation via the TCA cycle.
