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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Audiol Neurootol. 2013 Sep 5;18(5):10.1159/000353534. doi: 10.1159/000353534

Figure 1.

Figure 1

Upper panel: TMPA timecourse recorded from the basal turn of scala tympani following round window irrigation with 20 mM TMPA commencing at zero time, followed by implantation, indicated by the gray, noisy area. The gray, noisy region was when a cochleostomy was drilled and an implant inserted into ST. The noise results from electrical pickup by the high impedance microelectrode due to nearby motion and does not represent actual TMPA concentration change. TMPA irrigation was terminated at the time of implantation, but TMPA solution remained in the RW niche. Following implant insertion the measured TMPA became substantially higher but then declined progressively with time. Lower panel: TMPA concentration during the implantation procedure shown with expanded time scale and with exact event timings derived from audio recordings of the procedure. The lines indicate the start and end of each procedure. Even though the trace is noisy due to movements near the microelectrode, it is apparent that the large increase of concentration is associated with making the cochleostomy, rather than the insertion of the cochlear implant electrode.