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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Biomaterials. 2013 Oct 4;35(1):10.1016/j.biomaterials.2013.09.053. doi: 10.1016/j.biomaterials.2013.09.053

Figure 5.

Figure 5

Inflammatory response of whole human blood to silk substrates. All samples were incubated with blood for 2 h and inflammatory response was measured. (A) Complement fragment C5a in the plasma and leukocyte activation by monitoring CD11b expression. (B) Complement levels of Bb and C4d in the plasma as an indicator for the alternate and classical pathway, respectively. Dashed lines indicate initial levels. (Statistical differences between sample pairs examining the impact of endothelial cells were analyzed with the Student’s t-test, whereas differences between PTFE control and silk films were determined using one-way ANOVA and Dunnett’s multiple comparison post hoc test *P<0.05; **P<0.01; ±SD; n=3). Samples are defined in Figure 4 and the experimental set up is shown in Figure 1.