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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Leukemia. 2013 Mar 4;27(7):1548–1557. doi: 10.1038/leu.2013.68

Figure 2. Notch target gene signatures are enriched in human APL cells.

Figure 2

GSEA plots of 22 APL samples compared to 5 normal promyelocyte (Pro) samples demonstrate significant enrichment in APL of A) a previously described set of Notch transcriptional targets in T-ALL33 and B) a previously published set of transcriptional targets of Notch whose expression is inhibited by both gamma secretase inhibitor treatment and DNMAML expression34. Normalized enrichment scores-A: 1.6523; B: 1.1921.