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Treatment framework and minimal residual disease (MRD) stratification in the ALL2004 study. Patients with MRD levels ≥10−3 at week 12 received salvage therapy (dotted arrows), whereas the remainder continued to receive the initial risk-adapted therapy (solid arrows). Treatment schedules are shown in Table 1. CRT indicates cranial radiotherapy; HR, high-risk group; HHR, high-high-risk group; SR, standard-risk group.
