Table 4.

Comparison of differences in insulin-like growth factor (IGF)-1 and IGF binding proteins (IGFBP)-3 from baseline between the AQ, Lyo, and Spanish studies.

	Months	n	Mean difference from baseline	95% CI
AQ study*
IGF-I (ng/mL)	3	43	60.4	39.2, 81.7
	6	43	134.6	102.0, 167.2
	9	43	171.5	126.3, 216.6
	12	43	217.0	177.3, 256.7
	15	43	214.8	167.4, 262.1
	18	42	276.6	228.8, 324.4
IGFBP-3 (ng/mL)	3	43	1600	1150, 2050
	6	43	1140	650, 1640
	9	43	1380	720, 2050
	12	43	2170	1700, 2640
	15	43	2750	2280, 3220
	18	42	2680	2110, 3240
Lyo study†
IGF-I (ng/mL)	3	51	80.1	66.8, 93.4
	6	51	103.7	86.0, 121.4
	9	51	120.1	100.5, 139.6
	12	51	129.5	110.2, 148.9
IGFBP-3 (ng/mL)	3	51	981.5	793.3, 1169.6
	6	51	1083.6	821.1, 1346.2
	9	51	1136.0	952.2, 1319.8
	12	51	915.4	733.9, 1096.8
Spanish study
IGF-I (ng/mL)	3	64	83.8	61.5, 106.1
	6	65	99.2	79.5, 118.9
	12	63	123.2	100.4, 146.0
	18	63	143.9	120.2, 167.6
IGFBP-3 (ng/mL)	3	64	693.2	483.6, 902.7
	6	65	880.2	657.6, 1102.7
	12	63	1052.5	830.4, 1274.5
	18	63	1054.3	826.8, 1281.7

*Group B of AQ study.

†Data unavailable for months 15 and 18.

Number of patients varies depending on the available data at each visit.