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. Author manuscript; available in PMC: 2013 Dec 26.
Published in final edited form as: Mol Cell. 2012 Aug 30;47(5):10.1016/j.molcel.2012.07.030. doi: 10.1016/j.molcel.2012.07.030

Figure 3. Co-binding of TFs in regulatory regions.

Figure 3

A. We define the TF complexity of a regulatory region as the number of TF bound to it (Roy et al., 2010). The heatmaps show for every TF a distribution of the complexities associated with its bound regions. The left heatmap shows the original data while the right heatmap is obtained from a random process in which the TF complexity of every region is proportional to its length (Methods). B. TF co-binding at similar regions. Significant TF pairs (p<10−3, Methods) are color-coded by their respective fold enrichment. Selected overlaps are highlighted.