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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neuropharmacology. 2013 Oct 21;77:10.1016/j.neuropharm.2013.10.005. doi: 10.1016/j.neuropharm.2013.10.005

Figure 3. Kappa receptor ligands diminish the action of ethanol.

Figure 3

A. Top: superfusion of ethanol (EtOH) onto this neuron increased the amplitude of the evoked IPSP with recovery to control level upon washout. RMP was −80 mV. Bottom: pooled data showing the time course of the effect of ethanol, which on average increased inhibitory transmission by 48%. B. Dynorphin (1–2 μM; t = 0) decreased IPSPs to 79% of control. Addition of 44 mM ethanol (t = 15) reversed the dynorphin effect, increasing IPSPs by a net 32%. C. We observed a similar pattern with U69: U69 alone (0.5–1 μM) decreased IPSPs to 81% of control and addition of ethanol reversed the U69 effect, increasing IPSPs by a net 29%.