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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neuropharmacology. 2013 Oct 21;77:10.1016/j.neuropharm.2013.10.005. doi: 10.1016/j.neuropharm.2013.10.005

Figure 5. Ethanol and norBNI reciprocally block each others’ effect on GABA transmission.

Figure 5

A. Top: in this neuron, superfusion of norBNI increased the IPSP but subsequent addition of ethanol in the continued presence of norBNI had no further effect. RMP was −77 mV. Bottom: graph depicting the complete lack of ethanol effect with KORs blocked. B. Top: reciprocally, ethanol applied first increased the IPSP amplitude but further addition of norBNI was without effect. Bottom: graph average showing the average effect of the sequence ethanol then norBNI. C. Bar graph summarizing the influence of the dynorphin/KOR system on the effect of ethanol in CeA neurons. The effect of ethanol was significantly diminished by activation of KORs but completely obliterated by KOR blockade. D. The ethanol-induced decrease of the paired-pulse ratio was also affected by the KOR ligands and obliterated by the KOR antagonist, consistent with a presynaptic of interaction.