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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Future Neurol. 2013 Nov 1;8(6):10.2217/fnl.13.40. doi: 10.2217/fnl.13.40

Figure 1. Summary of the interaction among environmental factors, genetic preconditioning, hemodynamic stress and inflammation in aneurysm formation and progression to rupture (facing page).

Figure 1

ECM: Extracellular matrix; M1: Proinflammatory macrophage; M2: Anti-inflammatory macrophage; NO: Nitric oxide; ROS: Reactive oxygen species; VSMC: Vascular smooth muscle cell.