Fig. 4.

Topological domains with low gene expression and regulation (LL). (A) Boxplots comparing LL tissue-shared domains with all other domains for length, and prevalence of repeats, gene deserts, and housekeeping genes compared 1000 times with 29 random domains with a similar length. p values above the boxplots are based on a Wilcoxon test for the domain length and a Kolmogorov–Smirnov test for the other comparisons. (B) Enriched GO terms in shared LL domains. (C) Enriched GO terms in cortex tissue-specific LL domains. Dark blue bars represent GO terms that have an FDR ≤ 0.05. −log(EASE) p values generated by DAVID (Huang et al. 2009a, 2009b) are shown in the x axis and to the right of each dark blue colored bar are its FDR p values.