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Cytotoxicities and Antibacterial Activities of 1–9
| compound | HCT-116 | MRSA inhibition |
|---|---|---|
|
| ||
| IC50 (μg/mL) | MIC (μg/mL) | |
| Napyradiomycin 1 | 4.19 | 16 |
| Napyradiomycin 2 | >20 | 64 |
| Napyradiomycin 3 | >20 | >64 |
| Napyradiomycin 4 | 16.1 | >64 |
| Napyradiomycin 5 | 4.81 | >64 |
| Napyradiomycin 6 | 9.42 | >64 |
| Napyradiomycin B2 (7) | 3.18 | 32–64 |
| Napyradiomycin B3 (8) | 0.19 | 2 |
| Napyradiomycin B4 (9) | 1.41 | 32 |
