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. 2013 Oct 25;36(4):465–474. doi: 10.1590/S1415-47572013005000040

Figure 1.

Figure 1

A schematic representation of the canonical biogenesis of miRNA. Initially, a long hairpin-shaped (pri-miRNA) is transcribed by RNA polymerase II and then cleaved by Drosha (to yield pre-miRNA) prior to leaving the nucleus; the molecule is subsequently cleaved by a Dicer enzyme to yield double-stranded mature miRNA. Finally, miRNA is incorporated into the RNA-induced silencing complex (RISC), thereby allowing separation of the functional strand that interferes with mRNA by repressing translation or cleaving mRNA.