Table 5.
Baseline characteristics of stable versus decline outcome groups within the NCI and SCI baseline categories
| Baseline category |
NCI (n = 47) |
SCI (n = 166) |
||||
|---|---|---|---|---|---|---|
| Outcome | Stable (n = 40) | Decline (n = 7) | P value* | Stable (n = 76) | Decline (n = 90) | P value† |
| Age, mean, y | 62.54 (8.39) | 73.04 (5.94) | .007‡ | 65.28 (8.93) | 69.43 (8.39) | .002‡ |
| Education, y | 16.00 (2.36) | 16.57 (2.51) | .561 | 16.21 (1.96) | 15.08 (2.99) | .005‡ |
| MMSE | 29.63 (0.87) | 29.71 (0.49) | .793 | 29.29 (1.09) | 28.71 (1.20) | .002‡ |
| BCRS, total score§ | 5.68 (0.89) | 6.14 (0.90) | .204 | 8.54 (1.70) | 9.32 (1.50) | .002‡ |
| BCRS axis 1: concentration and calculation | 1.27 (0.60) | 1.29 (0.76) | .967 | 2.01 (0.82) | 2.41 (0.72) | .001‡ |
| BCRS axis 5: daily functioning | 1.08 (0.27) | 1.29 (0.49) | .099 | 1.65 (0.48) | 1.88 (0.47) | .002‡ |
| HAM-D, total score§ | 3.35 (3.36) | 1.86 (2.12) | .264 | 4.07 (4.28) | 4.74 (4.14) | .302 |
| HAM-D item 10: tension, worry | 0.53 (0.78) | 0.00 | .086 | 0.43 (0.74) | 0.76 (0.93) | .016¶ |
| HAM-D item 12: decreased appetite | 0.00 | 0.14 (0.38) | .015¶ | 0.01 (0.12) | 0.02 (0.15) | .665 |
| BEHAVE-AD total score§ | 0.76 (1.48) (n = 33) | 0.00 (n = 3) | .338 | 1.16 (1.72) (n = 58) | 1.39 (1.68) (n = 74) | .438 |
| PDS§ | 1.80 (1.00) (n = 35) | 2.18 (0.54) | .331 | 1.75 (0.96) (n = 72) | 2.56 (1.20) (n = 84) | .000** |
| Paired associates initial recall | 5.21 (2.20) (n = 39) | 4.14 (1.35) | .226 | 5.22 (2.31) | 4.17 (2.22) | .003‡ |
| Paired associates delayed recall | 5.85 (2.56) (n = 39) | 4.14 (1.46) | .096 | 5.66 (2.47) | 4.47 (2.78) | .004‡ |
| Digit span forwards | 6.86 (1.57) (n = 37) | 7.29 (0.95) | .484 | 7.26 (1.14) (n = 73) | 6.58 (1.21) (n = 86) | .000** |
| Digit span reverse | 5.54 (1.57) (n = 37) | 5.86 (1.10) | .614 | 5.86 (1.31) (n = 73) | 5.12 (1.43) (n = 86) | .001‡ |
| Digit symbol substitution test | 57.00 (11.0) (n = 39) | 46.71 (7.0) | .021¶ | 54.55 (13.6) | 48.76 (11.2) | .003‡ |
| WAIS vocabulary | 67.39 (10.0) (n = 39) | 71.29 (7.93) | .335 | 70.49 (6.71) | 62.91 (15.2) | .000** |
NOTE. Values are expressed as means and standard deviations (SDs).
Abbreviations: NCI, no cognitive impairment; SCI, subjective cognitive impairment; y, years; MMSE, Mini-Mental State Examination; BCRS, Brief Cognitive Rating Scale; HAM-D, Hamilton Depression Scale; BEHAVE-AD, Behavioral Pathology in Alzheimer’s Disease rating scale; PDS, Psychometric Deterioration Score; WAIS, Wechsler Adult Intelligence Scale.
For the NCI baseline group, P values for the outcome group differences were obtained with the Wilcoxon Rank Sum Test.
For the SCI baseline group, P values for the outcome group differences were obtained from independent samples t tests.
P < .01.
For the BCRS, HAM-D, the BEHAVE-AD scale, and the individual constituent tests of the PDS, only individual items or tests that are found to be significant in either the NCI or the SCI subject groups are shown. HAM-D item 10 assesses psychic anxiety including subjective tension and irritability and worrying about minor matters. HAM-D item 12 assesses loss of appetite.
P < .05.
P < .001.