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. 2013 Dec 26;9(12):e1004028. doi: 10.1371/journal.pgen.1004028

Table 1. Methylation level of CpG island with an MBD3 peak that fall into within the indicated levels of DNA methylation as determined by RRBS.

Methylation levels (x) MBD3 associated CpGs Total CpGs P value
x = 0% 538 (4.33%) 1023 (4.73%) 0.08758
0<x<10% 7178 (57.71%) 10348 (47.89%) <2.2e-16
10≤x<20% 522 (4.20%) 775 (3.59%) 0.005042
20≤x<30% 324 (2.60%) 514 (2.38%) 0.207
30≤x<40% 259 (2.08%) 431 (1.99%) 0.6071
40≤x<50% 213 (1.71%) 358 (1.66%) 0.7319
50≤x<60% 219 (1.76%) 398 (1.84%) 0.6189
60≤x<70% 220 (1.77%) 464 (2.15%) 0.01847
70≤x<80% 252 (2.03%) 639 (2.96%) 2.66E-07
80≤x<90% 584 (4.70%) 1507 (6.97%) <2.2e-16
90≤x≤100% 2129 (17.12%) 5153 (23.85%) <2.2e-16
Total 12438 (100.00%) 21610 (100.00%)

CpG islands bound by MBD3 (see Methods) were binned by methylation level (see Methods). Enrichment or depletion of MBD3 in each bin was determined by two-tailed t-test. Significantly enriched or depleted bins (p<0.001) are highlighted in bold.