Table 7. Allele, genotype and haplotype frequencies of the -845T>C, -738T>A and -353T>A polymorphisms in the IL8 promoter region in Afro-Brazilian and Admixed-Brazilians patients and controls.
| SNP |
Afro-Brazilians
|
Admixed Brazilians
|
||
|---|---|---|---|---|
| Periodontitis | Controls | Periodontitis | Controls | |
| N = 15 | N = 14 | N = 109 | N = 173 | |
| n (%) | n (%) | n (%) | n (%) | |
| -845 | ||||
| T | 28 (93.3) | 28 (100) | 212 (97.2) | 342 (98.8) |
| C | 2 (6.7) | 0 (0) | 6 (2.8) | 4 (1.2) |
| TT | 13 (86.7) | 14 (100) | 104 (95.4) | 169 (97.7) |
| TC | 2 (13.3) | 0 (0) | 4 (3.7) | 4 (2.3) |
| -738 | ||||
| T | 30 (100) | 28 (100) | 217 (99.5) | 345 (99.7) |
| A | 0 (0) | 0 (0) | 1 (0.5) | 1 (0.3) |
| TT | 15 (100) | 14 (100) | 108 (99.1) | 172 (99.4) |
| TA | 0 (0) | 0 (0) | 1 (0.9) | 1 (0.6) |
| -353 | ||||
| T | 18 (60.0) | 11 (39.3) | 112 (51.4) | 187 (54.0) |
| A | 12 (40.0) | 17 (60.7) | 106 (48.6) | 159(46.0) |
| TT | 5 (33.3) | 3 (21.4) | 29 (26.6) | 50 (28.9) |
| TA | 8 (53.3) | 5 (35.7) | 54 (49.5) | 87 (50.3) |
| AA | 2 (13.3) | 6 (42.9) | 26 (23.9) | 36 (20.8) |
| -845-738-353 | ||||
| TTT | 18 (60) | 11 (39.3) | 113 (51.8) | 187 (54.0) |
| TTA | 10 (33.3) * | 17 (60.7) * | 98 (45.0) | 154 (44.5) |
| TAA | 0 (0) | 0 (0) | 1 (0.5) | 1 (0.3) |
| CTA | 2 (6.7) | 0 (0) | 6 (2.8) | 4(1.2) |
| -845-738-353/-845-738-353 | ||||
| TTT/TTA | 6 (40.0) | 5 (35.7) | 51 (46.8) | 84 (48.6) |
| TTT/TTT | 5 (33.4) | 3 (21.4) | 29 (26.6) | 50 (28.9) |
| TTA/TTA | 2 (13.3) | 6 (42.9) | 23 (21.1) | 34 (19.7) |
| TTT/TAA | 0 (0) | 0 (0) | 1 (0.9) | 1 (0.6) |
| TTA/CTA | 0 (0) | 0 (0) | 2 (1.8) | 2 (1.2) |
| CTA/TTT | 2 (13.3) | 0 (0) | 2 (1.8) | 2 (1.2) |
* p-value = 0.067; OR = 0.3; 95% CI = 0.1- 0.9.
The genotypes -845CC, -738AA and TAT, CTT, CAT, CAA and CTA/CTA were not found in patients and controls.