Table 2. Resume of the significant two-tailed bivariate correlation results between ERBB2 RNA, erbB-2 protein expression levels, and clinicopathological features of mammary lesions.
Protein | RNA | Sequence Variants | ||||||||||
CB11/Int | CBE356/Ext | Conc ratio X 100 | Lesion/normal ratio | g.271 T>G | g.280 G>A | g.311 G>A | g.327 T>G | g.335 C>T | g.1754 A>C | g.1914 G>C | g.1994 del A | |
Clinicopathological Features | ||||||||||||
Histological Class | n#* | n* | ||||||||||
Age (Years) | p* | |||||||||||
Lesion size | p* | p* | ||||||||||
Pleomorphism | n* | |||||||||||
Lesions number | n* | |||||||||||
Lymphatic invasion | p** | p** | p** | |||||||||
Vascular infiltration | p* | |||||||||||
Clinical Outcome | n* | n* | ||||||||||
Protein | Ni | |||||||||||
CB11/int | p* | p* | p* | |||||||||
CBE356/ext | ||||||||||||
RNA | Ni | |||||||||||
Conc_ratio_X_100 | p* |
The significant values of the Pearson's correlation analysis were confirmed by the Spearman's test.
(#) Significant correlation only by Spearman's test.
(*) Correlation is significant at the 0.05 level.
(**) Correlation is significant at the 0.01 level.
(p: positive; n: negative) Indication of the direction of the relationship between variables.
(Ni) Sequence variants were not included in correlation test with RNA RT-qPCR and protein IHC.