Figure 5. Core network constructed out of core TFs.

The sub-network is constructed from 24 core TFs and their dysregulated IC genes. Several interactions have been confirmed by other researches. For example, the interactions between NFATC1 and IL6, and STAT3 and AKT1, which have been confirmed by biological experiments, are illustrated by the two inserted dashed rectangle and offered with detailed information on how it works. Core TFs are highlighted in red with bigger size. Genes with genetic variations offered by March et al. are marked with a small five-pointed star.