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. 2013 Dec 26;8(12):e83602. doi: 10.1371/journal.pone.0083602

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© 2013 Destici et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Relative mRNA expression profiles of Dbp in the liver (A), kidney (B), small intestine (C), and skin (D) of light-entrained (LD 12:12) wild type (black), Cry1^-/- (green) and Cry2^-/- (red) mice, as measured by RT-qPCR. For each genotype, mRNA levels (mean ± s.e.m) are expressed relative to the peak of expression (set at 100%) and fitted with a wave curve. The two-way ANOVA test revealed a significant effect of genotype and time interaction (*p<0.05). Data at ZT0 and ZT24 are double-plotted for easier visualization of daily expression. The bar above panels indicates time of light on and off.