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. 2013 Dec 26;9(12):e1003840. doi: 10.1371/journal.ppat.1003840

Figure 3. Inhibitory coverage against laboratory and field isolates.

Figure 3

(A) One-cycle GIA at 1.25 mg/ml total IgG pool from 3 rabbits tested by the NIH pLDH assay. GIA of anti-QV was compared to trivalent and bivalent vaccine groups and antibodies against P. berghei AMA1 (PbAMA1) were tested as the negative control. Strains CP803, CP806, CP830, CP845, and CP887 were recent culture adapted Cambodian isolates and HB3, GB4, MT/S1, C2A, W2mef were laboratory strains. Lines are median inhibition across strains. (B) One-cycle GIA at 1 mg/ml total IgG pool from 3 rabbits conducted by the WRAIR flow-cytometric method against 8 parasite strains. (*) indicates, p<0.05; (***) p<0.0001 (corrected for multiple comparisons). (C) Two-cycle GIA at 1 mg/ml pooled IgG conducted by the Burnet Institute flow-cytometric method. Strains CSL-2, HCS-E5, 2006, 2004, XIE were recently culture adapted field isolates from Africa, Asia and isolates E8B07, CAMP, D10, K1, T996 were laboratory strains [43].