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. 2013 Dec 26;8(12):e85071. doi: 10.1371/journal.pone.0085071

Table 1. Criteria for assessment of intended actions.

Coded Reason for DDI Alert Override Criteria
1. Will monitor as recommended Test ordered within the specified time period (see Table 2 )
2. Patient has already tolerated combination Five half-lives of the newly started or more recently started medicine have elapsed
3. No reasonable alternative Evidence suggests that no other drug within the same therapeutic class was a safer alternative, and/or appropriate monitoring/dose adjustment was conducted
4. Will adjust dose as recommended The dose was adjusted according to the alert recommendations, or If no recommended dose was specified, the appropriate monitoring was carried out and any necessary dose adjustment made during the course of treatment.