Figure 3.

Tumor histological characteristics. Morphological features of pancreatic cancer xenografts treated with MMC. Representative photomicrographs of H&E-stained histological sections of untreated xenografts and xenografts treated at 1, 4, and 7 days were obtained. A PALB2^+/− cell line had a heterozygous PALB2 mutation, and PALB2^−/−1 had a homozygous PALB2 deletion. Black arrows indicate apoptotic bodies/debris; red arrow, a ballooned cell with disorganized chromosomes; white arrow, a multinucleated cell in PALB2^−/−1. By contrast, no morphological changes were seen in treated PALB2^+/− tumors.