Table 1.
Gene Panel
| Tier 1: Currently actionable | Tier 2: Actionable in the near future | Tier 3: Frequently mutated | Germline pharmacogenomics | ||||
|---|---|---|---|---|---|---|---|
| ABL1 | KIF5B | ABL2 | MAPK1 | APC | PTCH1 | ABCB1 | SLC22A2 |
| AKT1 | KIT | AKT2 | MC1R | BAK1 | PTPN11 | ABCC2 | SLCO1B3 |
| ALK | KRAS | AKT3 | MCL1 | BCL2 | PTPRD | ABCC4 | SOD2 |
| ASXL1 | MAP2K1 | ATM | MDM2 | CDH1 | RB1 | ABCG2 | SULT1A1 |
| AURKA | MET | AURKB | MDM4 | CDKN2A | RICTOR | C1orf144 | TPMT |
| BAP1 | MLL | BCOR | MEN1 | CREBBP | RPS14 | COMT | TYMS |
| BCR | KRAS | CBL | MITF | CRLF2 | SF1 | CYP1B1 | UGT1A1 |
| BCL2L11 | MPL | CBLB | MLH1 | CSF1R | SF3B1 | CYP2C19 | UMPS |
| BRAF | NKX2-1 | CDK6 | MRE11A | CTNNB1 | SMAD2 | CYP2C8 | |
| BRCA1 | NPM1 | CHEK1 | MSH2 | EPHA3 | SMAD3 | CYP2D6 | |
| BRCA2 | NRAS | CHEK2 | MSH6 | EPHA5 | SMAD4 | CYP3A4 | |
| CCND1 | PDGFRA | ERBB3 | MYC | EPHB6 | SMARCA4 | CYP3A5 | |
| CCNE1 | PIK3CA | ERBB4 | MYCN | ETV6 | SMARCB1 | DPYD | |
| CDK4 | PML | FBXW7 | NF2 | EZH2 | SPRY4 | EIF3A | |
| CDK8 | PTEN | FGFR1 | NOTCH1 | FGFR3 | SRC | ERCC2 | |
| CEBPA | RARA | FLT1 | PAX5 | GAB2 | TFG | ESR1 | |
| DDR2 | ROS1 | FLT4 | PDGFRB | GATA1 | TGFBR2 | ESR2 | |
| DNMT3A | RET | GATA2 | PIK3R1 | GNAS | TRRAP | FCGR1A | |
| EGFR | STK11 | GNA11 | PMS2 | GRIN2A | U2AF1 | FCGR2A | |
| EML4 | TP53 | GNAQ | RAF1 | HNF1A | U2AF65 | FCGR3A | |
| EPHB2 | VHL | GRM3 | RUNX1 | IL7R | ZRSR2 | GSTP1 | |
| ERBB2 | HDAC4 | SMO | JAK1 | GUCY1A2 | |||
| FGFR2 | HRAS | SRSF2 | MAP2K4 | ITPA | |||
| FGFR4 | IGF1R | SUZ12 | MUTYH | LRP2 | |||
| FLT3 | IKZF1 | TSC1 | MYCL1 | MAN1B1 | |||
| HIF1A | JAK3 | TSC2 | NF1 | MTHFR | |||
| IDH1 | KDM6A | TET2 | NOTCH2 | NQO1 | |||
| IDH2 | KDR | TYR | PBRM1 | NRP2 | |||
| JAK2 | MAP2K2 | WT1 | PRPF40B | SLC22A1 | |||