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CNTF/P-STAT3 double-labeling of coronal sections of the tuberal hypothalamus from CNTF-treated control (A–C), HFD (D–F) and CR (G–I) mice. Compared with controls (A,B) the greater CNTF expression seen in tanycytes of HFD mice (D) is matched by increased CNTF responsiveness (E). In CR mice both CNTF expression (G) and responsiveness (H) are lower than in control mice and, especially, HFD mice. Bar: 100 μm.
