Figure 4.

Evaluation of Gacyclidine effects on the spontaneous motor activity of hSOD1^G93A mice: Open Field analysis. Spontaneous locomotor activity represented by the mean distance covered by female controls and hSOD1^G93A mice in a weekly 8 min recording test over disease progression included. (A,B)—Control and hSOD1^G93A mice injected with NaCl or GK11 0.1 mg/kg. (C,D)—Control and hSOD1^G93A mice injected with NaCl or GK11 1 mg/kg. A minimum of 5 animals were analyzed per time point. Statistics: two ways ANOVA followed by Tukey Kramer test.