Table 4.

Summary of SR-PK/PD modeling results for Class II HAP.

	Antitumor activitya		Tumor selectivityb	Systemic effector releasec
	HAP only	HAP+ radiation
kmetP,max ↑	↑ ↑	↑ ↑	↓	↑ ↑
kmetE ↑(case 1)	↑ ↑	↑ ↑	↓	↓ ↓
kmetE ↓(case 2)	↑ ↑	↑ ↑	~	↑ ↑
DE ↑	↑	↓	↑	↑
ktE ↑	↑	↓	↑ ↑	↑

↑ increase; ↓ decrease; ~ no substantial change.

^aOverall cell kill predicted in the 3D FaDu tumor microregion (see Figures 5 and 7).

^bRatio of overall cell killing in the tumor and cremaster muscle microregions (see Figures 5 and 7).

^cOverall effector released into the circulation by the FaDu tumor microregion (see Figure 8).