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. 2004 Mar 23;101(14):4954–4959. doi: 10.1073/pnas.0401141101

Fig. 1.

Fig. 1.

(A) Regions sampled by LCM for mutational analysis in SK and SCCs. 1, uninflamed upper; 2, uninflamed lower; 3, inflamed upper; 4, inflamed lower; 5, stromal; 6, normal upper; 7, normal lower (note that only regions 6 and 7 sampled in normal control skin). (B) Distribution of UVB fingerprint mutations in SK, SCC, and normal skin. U, upper epidermal regions 1 and 3; L, lower epidermal regions 2 and 4. Normal U and Normal L are the mutations in the upper and lower epidermal regions, respectively, of control samples from non-sun-exposed skin. Region 6 and 7 (normal skin adjacent to the SK or SCC) data are not shown for these regions. (C) Distribution of UVA fingerprint mutations in SK, SCC, and normal skin. (D) Number of cells positive for CPDs as determined by IHC. The minimal number of CPD-positive cells in normal control skin is too small to be visualized. (E) Number of cells positive for 8-oxoG as determined by IHC. (F) Number of cells positive for p53 as determined by IHC.