Table 3. Types of mutations detected in exons 5-9 p53 in the stratum granulosum of human SCC.

Base change (total no.)	Coding strand	Codon p53	Sequence	AA change*	Lesion region†
UVA fingerprints
AT → CG (1)	A → C	311	caAca‡	Asn → Thr	SCC4,1
UVB fingerprints	C → T	289	ctCc‡	Leu → Leu	SCC1,1
GC → AT (9)	C → T	157	gtCc‡	Val → Val	SCC1,6
	C → T	233	cCact‡§	His → Tyr	SCC1,3
	C → T	318	cCaa‡§	Pro → Leu	SCC4,1
	C → T	314	tCct‡	Ser → Phe	SCC4,3
	C → T	296	tCacc‡	His → Tyr	SCC4,6
	C → T	251	atCc‡	Ile → Ile	SCC7,1
	G → A	197	aGtgg‡	Val → Met	SCC3,1
	G → A	226	gGct‡	Gly → Asp	SCC6,6
ROS¶
GC → TA (6)	G → T	290	cGca	Arg → Leu	SCC4,6
	C → A	195	atCc‡	Ile → Ile	SCC3,1
	C → A	208	gaCa	Asp → Glu	SCC3,1
	C → A	312	acCa‡§	Thr → Thr	SCC4,1
	C → A	309	cCca‡§	Pro → His	SCC4,3
	C → A	313	agCt‡	Ser → Arg	SCC4,3
GC → CG (6)	G → C	271	tGagg‡	Glu → Gln	SCC1,3
	G → C	228	tGact‡	Asp → His	SCC6,6
	G → C	326	aGaat‡	Glu → Gln	SCC6,6
	C → G	190	cCtc‡§	Pro → Arg	SCC1,1
	C → G	252	cCtca‡§	Leu → Val	SCC7,1
	C → G	301	gCccc‡	Pro → Ala	SCC1,3
GC → AT (1)	C → T	310	aaCa	Asn → Asn	SCC4,1
Other changes
AT → GC (3)	T → C	195	aTcc‡	Ile → Thr	SCC1,1
	A → G	196	cgAg‡	Arg → Arg	SCC3,1
	A → G	249	gAggc‡	Arg → Gly	SCC1,1
AT → TA (3)	T → A	134	gTttt‡	Phe → Ile	SCC1,6
	A → T	195	tAtcc	Ile → Phe	SCC1,1
	A → T	310	aAca‡	Asn → Ile	SCC4.3
CpG sites (2)	C → T	152	cCgc‡§	Pro → Leu	SCC1,6
	C → T	158	cCgcg‡§	Arg → Cys	SCC1,6

Codons in bold type refer to hot-spot codons.

^*Amino acid changes are shown in bold type.

^†Lesion number and region laser-captured as defined in Fig. 1A.

^‡Base-pair substitutions occur at Py-Py sites or Py runs on either nontranscribed or transcribed strand.

^§5′G of 5′-GG-3′ on either nontranscribed or transcribed strand.

^¶Base changes potentially attributable to UVA indirectly through the production of ROS, not used as UVA fingerprints for data analysis.