FIGURE 6.

Models of Aβ protofibril dissociation into monomers compatible with exponential decay kinetics. A, rate-limiting dissociation of protofibril subunits at a rate that is independent of the subunit position within the linear assembly. B, pre-equilibrium of linear and nonlinear protofibrils and rate-limiting dissociation of the latter into monomers. For illustration purposes, only one of the protofibril subunits (shown in magenta) dissociates. The indicated dissociation time constant (τ) was determined for Aβ42 protofibrils at 25 °C.