Figure 3. MRI features in Alexander disease: Periventricular and basal ganglia findings.

Axial fluid-attenuated inversion recovery (FLAIR) (A, B) and T2-weighted (C, D) MRIs from case 9 showing periventricular hyperintensity. Also shown is increased dentate signal (arrows in B) and periventricular T2 hypointensity (arrows in D). Sagittal T1-weighted MRI from case 9 (E) showing the periventricular T1 hyperintensity. Axial FLAIR MRI from case 12 (F) showing periventricular garlands. Axial T2 MRIs from case 2 (G) and case 4 (H) showing symmetrically increased signal along the medial and lateral borders of the lentiform nuclei (G) and globus pallidi (H), respectively.