Table 3.
Analgesic Activity of the Newly Synthesized Compounds Using the Rat Tail Withdrawal Technique
| Compounda | Reaction Time (sec)b | |||
|---|---|---|---|---|
| 0 | 1 h | 2 h | 4 h | |
| Control | 2.82± 0.10 | 2.93 ± 0.10 | 2.95 ± 0.10 | 2.98 ±0.20 |
| 7a | 2.92 ± 0.10 | 3.25 ± 0.20c (11)d |
3.68± 0.20c (26) |
3.99 ± 0.20c (36) |
| 7b | 2.75 ± 0.10 | 3.25 ± 0.20c (18) |
3.62 ± 0.20c (31) |
3.74 ± 0.20c (36) |
| 7c | 2.80 ± 0.10 | 3.95 ± 0.10 c (41) |
4.02 ± 0.20 c (43) |
4.25 ± 0.30c (51) |
| 7d | 3.12 ± 0.20 | 3.83 ± 0.20c (22) |
3.92 ± 0.20c (25) |
4.01 ± 0.20c (28) |
| 7e | 3.01 ± 0.30 | 4.10 ± 0.20 c (36) |
4.25 ± 0.10c (41) |
4.46 ± 0.30c (48) |
| 7f | 3.01 ±0.30 | 4.11 ±0.20 c (36) |
4.31 ±0.20 c
(43) |
4.51 ±0.20 c
(49) |
| 8a | 3.10 ±0.20 | 3.92 ±0.20 c (26) |
4.25 ±0.30 c
(37) |
4.60±0.20c (48) |
| 8b | 2.73 ±0.10 | 3.15 ±0.10 c
(15) |
3.29 ±0.20 c (20) |
3.60 ±0.20 c
(31) |
| 8c | 2.80 ± 0.10 | 3.85 ± 0.10 c (37) |
4.15 ± 0.20c (48) |
4.42 ± 0.30c (57) |
| 8d | 3.10 ± 0.20 | 3.75 ± 0.20 c (20) |
3.93 ± 0.10 c
(26) |
4.05 ± 0.30c (30) |
| 8e | 3.05±0.20 | 3.82 ±0.30 c (25) |
4.12 ±0.20 c (35) |
4.35 ±0.20 c
(42) |
| 8f | 3.08 ±0.10 | 4.28±0.20 c (38) |
4.38 ±0.20 c (42) |
4.58 ±0.20 c
(48) |
| 9a | 3.15 ± 0.10 | 3.63 ± 0.20 c (15) |
3.85 ± 0.10 c (22) |
3.94 ± 0.10c (25) |
| 9b | 2.73± 0.20 | 3.71 ± 0.20c (43) |
3.92 ± 0.10c (43) |
3.96 ± 0.20c (45) |
| 9c | 2.89 ±0.20 | 3.68 ±0.20 c
(27) |
3.79 ±0.20 c (31) |
4.02 ±0.20c (39) |
| 10a | 2.85 ± 0.20 | 3.95± 0.10c (38) |
4.15 ± 0.20c (45) |
4.35 ± 0.20c (52) |
| 10b | 2.92 ± 0.10 | 4.05 ± 0.20c (38) |
4.12 ± 0.20c (41) |
4.25 ± 0.20c (45) |
| 10c | 2.74 ± 0.10 | 3.94 ± 0.20c (43) |
4.04 ± 0.30c (47) |
4.15± 0.30c (51) |
| 11a |
2.64 ± 0.10 | 3.24 ± 0.10c (22) |
3.28 ± 0.20c (24) |
3.42 ± 0.20c (29) |
| 11b |
2.82 ± 0.10 | 3.25 ± 0.10 c (15) |
3.40 ± 0.20c (20) |
3.69 ± 0.20c (30) |
| 11c | 3.10 ± 0.10 | 4.20 ± 0.30c (35) |
4.42± 0.20c (42) |
4.71± 0.20c (51) |
| Diclofenac Na | 2.78 ± 0.10 | 3.89 ± 0.30c (39) |
4.09 ± 0.10c (47) |
4.33 ± 0.20c (55) |
a
Dose levels, po: test compounds (20 mg / kg b.wt.), diclophenac Na (20 mg / kg b.wt.).
b
Values are expressed as mean ± S.E. (Number of animals N = 5 rats).
c
Significantly different compared to corresponding control.P ≤ 0.05.
d
Between parentheses (Percentage analgesic activity).