Figure 4. Coat color distribution by exposure.

The percentage of animals with each coat color across five categories for all A^vy/a animals (n = 170) separated by lead exposure group is shown. A significant increase in yellow offspring between control and 32 ppm exposure (p = 0.01) reflects a decrease in methylation of the A^vy allele. At the 2.1 ppm concentration, the percentage of pseudoagouti mice increased from 12 to 23%, indicating an increased frequency of highly methylated A^vy offspring in this group and suggesting a non-monotonic effect at this locus with low lead exposure.

A^vy: Viable yellow agouti.