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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Gastroenterology. 2013 Aug 16;145(6):10.1053/j.gastro.2013.08.018. doi: 10.1053/j.gastro.2013.08.018

Figure 2. Significantly increased activation of Ras and its downstream targets with elevated COX2 and F4/80+ macrophages.

Figure 2

Figure 2

(A) Ras activity was measured by a Raf-pull down assay and was correlated with Phospho-ERK expression levels. (B) Western blot analysis for phospho-ERK expression for BAC and LSL/BAC animals on both diets was performed. (C) Additionally, IHC for phospho-ERK from all groups of mice are shown. (D & E) Pancreas tissue sections from each mouse were stained for COX2 and F4/80.