Figure 5. Decreased overall survival and promotion of tumor growth with continuous consumption of HFD.
(A) The overall survival of LSL/BAC (CD; n=13 and HFD; n=11) and LSL/PDX-1 (CD; n=19 and HFD; n=10) animals on HFD was recorded. (B) Gross images of LSL/BAC animals on CD and HFD and the pancreases of these animals are shown. (C) Additionally shown are H&E stains of the pancreases of LSL/BAC animals on CD and HFD at 160 days and 205 days along with (D) histology of PDX-1 and Pdx-Cre-KrasG12D on CD and HFD from 90-137 days.