Table 3.
TFs prominently associated with significantly regulated genes
| TFBS family | TF/up (+) or down (−) regulated | pathway association | z-score all regulated promoters | z-score up-regulated promoters | z-score down-regulated promoters |
|---|---|---|---|---|---|
| OCT1 | POUF2 + | + | 5.5 | 5.07 | 2.55 |
| FKHD | FOXD1 + FOXP4 − FOXJ2 − |
− | 7.4 | 5.31 | 4.92 |
| IRF | IRF1 + IRF8 + |
− | 5.59 | 3.32 | 4.9 |
| CEBP | CEBPD + | + | 3.65 | 4.67 | - |
| BCDF | OTX1 + | − | 3.18 | 4.85 | - |
| STAT | - | + | 3.59 | 3.57 | - |
| HOMF | - | − | 8.03 | 7.3 | 4.33 |
| HOXF | - | − | 5.75 | 5.64 | 2.63 |
Column 1 shows the TFBS family of which the individual TFs shown in column 2 are members. Column 3 indicates whether the TF was directly implicated by an associated pathway and columns 4 to 6 indicate the statistical over-representation of the respective TFBS family as compared to all promoters in the human genome. Only factors that show at positive values in at least three columns are shown.