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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Eur Cytokine Netw. 2013 Jun;24(2):10.1684/ecn.2013.0336. doi: 10.1684/ecn.2013.0336

Table 6.

Ten pathways associated with the 190 up-regulated genes contained in the network

Pathway p-value input genes in pathway
Cytokine receptor degradation signaling 2.84E-04 ILA1, MAP3K2, IRAK4, IL4R, AKT2, IGF1R, FLT4, ITK, IL7, IL1B, PDGFRA, IFNG, SOCS3, BRAF, PRLR, PRKCD, SYK, FGFR2, ZAP70
IL-7 signaling pathway(JAK1 JAK3 STAT5) 5.82E-04 MAP3K2, IRAK4, PIK3CD, AKT2, IGFR1, FLT4, ITK, IL7, PDGFRA, BRAF, PRKCD, SYK, FGFR2, ZAP70
pertussis toxin-insensitive ccr5 signaling in macrophage 1.86E-03 CCL2, CCR5, JUN, CXCL12
AKT(PKB)-Bad signaling 1.95E-03 MAP3K2, IRAK4, PIK3CD, AKT2, IGFR1, FLT4, ITK, PDGFRA, BRAF, PRKCD, SYK, FGFR2, TZAP70
Migration 2.15E-03 MAP3K2, IRAK4, PIK3CD, AKT2, IGFR1, FLT4, ITK, PDGFRA, BRAF, PRKCD, SYK, FGFR2, ZAP70
ATF-2 transcription factor network 2.89E-03 DUSP8, I BCL2, NOS2, PDGFRA, IFNG, SOCS3
Signaling events mediated by PTP1B 3.92E-03 ITGB3, LAT, LYN, SOCS3, PRLR, CSF1R
IL23-mediated signaling events 4.23E-03 CCL2, NOS2, IL1B, IFNG, SOCS3
Class I PI3K signaling events 8.96E-03 ITK, LYN, VAV1, SYK, ZAP70
IL-6-mediated signaling events 9.85E-03 CEBPD, IRF1, VAV1, SOCS3, PRKCD

All associated pathways were ranked by their p-value as determined by the program GePS/GeneRanker (Genomatix Software, Munich). Input genes in pathways: these genes were part of the list of regulated genes as well as the pathway.