Table 8.

Final results: Core set of TFs involved in response to LIF

TF	Matrix family	pathway network	associated Pathway	TF regulated (+)/(−)	TF Framework associated	TFBS over-represented (+)/(−)
FOXD1	FKHD	+		−	+	−
FOXP4 - FOXJ2	FKHD	+	+	+		+
STAT 1/3/4/5a	STAT	+	+		+	+
CEBPD	CEBP	+	+	+		+
	SP1	+		+	+	+
IRF1 IRF8	IRF		+	+	+	−
	CREB		+	+	+
POU2F1	OCT1			−	+	−
OTX1	BCDF			+	+	+

The table summarizes the results from five analyses (pathway network, pathway association, TF gene up/down regulation, framework association, and TFBSs overrepresentation in promoters of up/down-regulated genes) derived from three independent lines of evidence: generic knowledge databases, experimental measurements, and promoter sequence analysis. Final selection was made with a cutoff of 3/5, i.e. only factors supported by at least 3 of the five analyses are shown. (+) and (−) indicate association with up (+) or down (−) regulated genes and are for the purpose of sum scores treated as equivalent.