Table 2.
Effect of 10% weight loss on clinical parameters stratified by insulin level
| Lower insulin ≤ 12 uIU/mL
|
Higher insulin > 12 uIU/mL
|
|||||
|---|---|---|---|---|---|---|
| Weight loss < 10%
|
Weight loss ≥ 10%
|
P value | Weight loss < 10%
|
Weight loss ≥ 10%
|
P value | |
| n = 59 | n = 50 | n = 37 | n = 62 | |||
| BMI, kg/m2 | −1.4 (0.5) | −10.3 (0.6) | <0.0001 | −0.7 (0.7) | −12.4 (0.5) | <0.0001 |
| SBP, mm Hg | 0 (2.1) | −8.4 (2.4) | 0.01 | −3.2 (2.5) | 3 (1.9) | 0.06 |
| DBP, mm Hg | −0.8 (1.2) | −1.7 (1.4) | 0.65 | 0.2 (1.5) | 2.8 (1.1) | 0.17 |
| Total cholesterol, mg/dL | −6.2 (4) | −13.9 (4.2) | 0.20 | −5.4 (5.2) | −13.7 (3.8) | 0.21 |
| Triglycerides, mg/dL | −6.8 (5.9) | −31.7 (6.2) | 0.01 | −7.3 (10.0) | −35.8 (7.4) | 0.03 |
| LDL-C, mg/dL | −4.3 (3.3) | −12 (3.5) | 0.12 | −4.2 (4.3) | −10 (3.1) | 0.28 |
| HDL-C, mg/dL | 0 (1.5) | 3.9 (1.6) | 0.1 | 0.2 (1.9) | 3.6 (1.4) | 0.16 |
| Glucose, mg/dL | −1.7 (2.7) | −7.3 (2.9) | 0.18 | 13.2 (5.4) | −13.5 (4.1) | <0.001 |
| Insulin, uIU/mL | 1.9 (0.9) | −3 (0.9) | <0.001 | −2.9 (1.8) | −14.2 (1.4) | <0.0001 |
| HOMA | 0.34 (0.21) | −0.82 (0.22) | <0.001 | 0.10 (0.95) | −4.33 (0.74) | <0.001 |
| HbA1c, % | −0.14 (0.07) | −0.51 (0.07) | <0.001 | −0.07 (0.15) | −0.95 (0.11) | <0.0001 |
Values are mean (SE) adjusted for baseline values for age, BMI, and the outcome of interest. ANCOVA was used to determine the difference in Δ clinical parameters between dichotomous weight loss groups.