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. Author manuscript; available in PMC: 2013 Dec 27.
Published in final edited form as: Circulation. 2011 Mar 1;123(8):10.1161/CIRCULATIONAHA.110.978528. doi: 10.1161/CIRCULATIONAHA.110.978528

Table 1.

Developmental changes in NO and ET-1 signaling in Shunt lambs

NO Signaling 1 week 2 week 4 week 8 week
eNOS protein levels ↔ ↔ ↑ ↔
Relative NOS activity ↔ ↓ ↓↓ ↓↓↓
Plasma NOx levels nd ↑ ↔ ↔
Lung Tissue NOx levels nd ↑ ↔ ↔
Nitrated eNOS nd ↑ ↑↑ ↑↑↑
Hsp90 protein levels nd ↔ ↔ ↔
eNOS bound Hsp90 nd ↓ ↓↓ nd
Plasma cGMP levels ↔ ↑ ↑ ↑
Lung tissue cGMP levels nd ↑ ↑ ↑
sGC-α protein levels nd ↑ ↑ ↔
sGC-β protein levels nd ↔ ↑ ↔
PDE5 protein levels nd ↔ ↑ ↔
PDE5 activity nd nd ↑ nd
Plasma BNP levels nd ↔ ↑ ↑
ET signaling 1 week 4 week 8 week
Plasma ET-1 nd ↑ nd
Immunoreactive ET-1 ↑ nd nd
preproET-1 mRNA ↔ ↔ nd
preproET-1 protein levels ↔ ↔ nd
ECE-1 mRNA nd ↑ nd
ECE-1 protein levels ↑ ↑ nd
ETA receptor protein levels ↔ ↑ ↑
ETB receptor protein levels ↓ ↓ ↔
*

nd=not determined