. Author manuscript; available in PMC: 2013 Dec 27.

Published in final edited form as: Nat Rev Microbiol. 2003 Nov;1(2):10.1038/nrmicro753. doi: 10.1038/nrmicro753

Table 3.

Type IV secretion substrates and host interacting partner proteins^*

Bacteria	Exported substrates	Host-cell interacting partners
Agrobacterium tumefaciens	VirD2	AtKAPα, CypA, PP2C, RocA, Roc4
	VirE2	VIP1, VIP2
	VirE3	?
	VirF	ASK (Skp1-like), VIP1

Helicobacter pylori	CagA	c-Src, SHP2, c-MET Grb2, ARP2/3, Csk, Rho GTPases, (Rac1,Cdc42), N-WASP, ZO-1, JAM

Bordetella pertussis	Pertussis toxin	αβγ heterotrimeric G proteins

Legionella pneumophila	RalF	ADP ribosylation factor (ARF)
	LidA	?
	DotA	?

Brucella spp.	?	?

Bartonella spp.	?	?

Rickettsia spp.	RalF?	?

Some protein–protein contacts might be mediated by mutual interactions with partner proteins.