Table 2.
Significant Associations Only, of HLA Class I Alleles and Mycobacterium tuberculosis Lineages in the South African Coloured Population of the Western Cape
| HLA Allele | Frequency (No.) | Strain | P Valuea | OR (95% CI)b |
|---|---|---|---|---|
| A*01 | 0.33 (167) | Beijing | .031 | 1.58 (1.04–2.40) |
| A*03 | 0.24 (120) | LAM | .022 | 1.65 (1.08–2.54) |
| B*07 | 0.25 (123) | LCC | .019 | 0.49 (.25–.89) |
| B*08 | 0.06 (31) | Beijing | .045 | 2.32 (1.02–5.13) |
| B*27 | 0.17 (84) | Beijing | .002 | 0.35 (.16–.68) |
| B*44 | 0.23 (114) | LCC | .007 | 2.07 (1.22–3.52) |
| B*58 | 0.17 (86) | Quebec | .001 | 2.69 (1.27–5.75) |
| C1 | 0.45 (243) | Beijing | .011 | 0.60 (.40–.89) |
| C2 | 0.32 (171) | Beijing | <.001 | 2.03 (1.35–3.08) |
Abbreviations: CI, confidence interval; HLA, human leukocyte antigen; OR, odds ratio.
a P value adjusted for age and sex. P values in bold are statistically significant.
b Odds of having a specific lineage, vs any other lineage, for each extra HLA allele carried.