Table 3.
Significant Associations Only, of HLA Class I Genotypes and Haplotypes With Mycobacterium tuberculosis Lineages in the South African Coloured Population of the Western Cape
| Lineage | HLA Factor | Frequency (No.) | P Valuea | OR (95% CI)b |
|---|---|---|---|---|
| Genotype | ||||
| LAM | A*01/A*01c | 0.13 (33) | .036 | 1 |
| A*01/A*02 | 0.11 (27) | 3.89 (1.37–11.04) | ||
| A*03/Undefined | 0.03 (8) | 6.33 (1.19–33.67) | ||
| Beijing | B*07/B*07c | 0.06 (15) | .001 | 1 |
| B*07/B*08 | 0.04 (10) | 19.6 | ||
| B*07/B*44 | 0.09 (23) | 10.4 | ||
| B*08/B*62 | 0.01 (3) | 25.4 | ||
| Beijing | C1/C1c | 0.23 (62) | <.001 | 1 |
| C1/C2 | 0.24 (65) | 3.61 (1.39–9.33) | ||
| C2/C2 | 0.12 (32) | 4.39 (1.49–12.97) | ||
| C2/Undefined | 0.16 (42) | 4.46 (1.62–12.29) | ||
| Haplotype | ||||
| Beijing | A*01-B*58-C1c | 0.07 (30) | <.001 | 1 |
| A*01-B*08-C2 | 0.05 (20) | 7.8 (1.2–50.0) | ||
| A*02-B*07-C2 | 0.05 (24) | 8.3 (1.5–45.6) | ||
| A*01-B*44-Undefined | 0.03 (17) | 7.6 (1.2 50.30) |
Abbreviations: CI, confidence interval; HLA, human leukocyte antigen; OR, odds ratio.
a P value for genotype and haplotype models, adjusted for age and sex. P values in bold are statistically significant.
b Odds of having a specific lineage and genotype or haplotype, vs any other lineage, compared to the reference genotype/haplotype (OR = 1). The 95% CI could not be calculated for HLA-B genotypes due to their very low frequencies in patients whose infections were not Beijing.
c Reference genotypes/haplotype—the most common (having the highest frequency, so assumed to be the wild type) homozygous genotype and haplotype in the study population.