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. 2004 Mar 29;101(14):5093–5098. doi: 10.1073/pnas.0400954101

Fig. 3.

Fig. 3.

Haloperidol presents opposite effects to DA-promoted bursts depending on the involvement of NMDA receptors. (A) Haloperidol attenuated DA-promoted bursts in the existence of NMDA receptor blockade. Bursting responses (most of 12 sweeps, 0.1 Hz) elicited after adding DA for 3 min (Top) were virtually eliminated (one bursting sweep; Left) after applying haloperidol (10 μM) for 3 min (Middle) and totally eliminated within 7 min (Bottom). (B) Haloperidol lowered DA bursting threshold in the absence of NMDA receptor blockade. By applying DA, DA-promoted bursts were initiated in the recorded cell with a stimulating strength of 7.0 μA (upper two rows). After applying haloperidol (100 nM), a 6.0 μA stimulus was enough to trigger the bursting (bottom two rows).