Table 5.
Subgroup Analysis and Dose-Response Relationship: Central Adiposity and Risk of BE
| Subgroups | Categories | No. of studies | Adjusted OR | 95% CI |
P value between groups (Pinteraction) |
|---|---|---|---|---|---|
| Study-related variables | |||||
| Study location | Asian | 1 | 1.45 | 0.82–2.55 | .31 |
| Western | 14 | 2.01 | 1.49–2.72 | ||
| Study design | Cross-sectional | 1 | 1.65 | 0.82–3.33 | .05a |
| C-C | 12 | 2.22 | 1.61–3.06 | ||
| Cohort | 2 | 1.27 | 0.93–1.73 | ||
| Study setting | Hospital-based | 10 | 2.30 | 1.59–3.31 | .10 |
| Population-based | 5 | 1.54 | 1.12–2.11 | ||
| Method of ascertainment | Measured | 14 | 2.08 | 1.58–2.74 | .02a |
| Self-reported | 1 | 1.20 | 0.83–1.74 | ||
| Central adiposity–related variables | |||||
| Adjusted for BMI | Yes | 5 | 1.88 | 1.20–2.95 | .79 |
| No | 10 | 2.03 | 1.45–2.84 | ||
| Reporting adiposityb | Categorical | 9 | 1.56 | 1.25–1.96 | .06 |
| Continuous | 6 | 2.77 | 1.61–4.75 | ||
| Different measures of central adiposity | Visceral adipose tissue area | 4 | 1.78 | 1.19–2.67 | .43 |
| WHR/WTR | 11 | 2.04 | 1.49–2.81 | ||
| WC | 11 | 1.58 | 1.25–1.99 | ||
| Length of BE | |||||
| Long-segment | 5 | 1.96 | 1.39–2.75 | .14 | |
| Short-segment | 5 | 1.34 | 0.93–1.94 | ||
| Dose-response relationship | |||||
| Central adiposity (reported as tertiles/quartiles) | Q2 (vs Q1) | 8 | 1.65 | 1.11–2.44 | .53 |
| Q3/Q4 (vs Q1) | 8 | 1.92 | 1.47–2.50 |
C-C, case-control; Q, quartile; WTR, waist-thigh ratio.
a
Statistical significance.
b
Comparison of studies that reported data as categories with studies that reported means and standard deviations of adiposity in cases with BE and controls without BE (unadjusted) and transformed into a binary OR by using a statistical equation.