Figure 3.

Activated matriptase is present in the ORS keratinocytes of the isthmus. Tissue sections of the upper surface portion of an anagen-phase human hair follicle were immunostained with the matriptase-specific mAb M32 (Matriptase) or the activated matriptase-specific mAb M69 (Activated Matriptase). Sections were also stained with a non-specific mouse IgG antibody as a negative control (not shown). The isthmus region of the hair follicles within the rectangle is shown at higher magnification (right panel). Nuclei of cells were counterstained blue with hematoxylin. Scale bar: 50 µm.