Table 1.
AT2 agonist | Type of vessel | Species | Effective concentration | Result | Reference |
---|---|---|---|---|---|
β-substituted Ang peptides | Aorta | Mouse | 10−12 to 10−6 M | Vasodilation in presence of AT1R blocker | 8 |
β-substituted Ang peptides | Aorta | Mouse | 10−12 to 10−6 M | Vasodilation in absence of AT1R blocker | 8 |
C21 | Aorta | Mouse | 10−10 to 10−6 M | Vasodilation in presence of AT1R blocker | 14 |
C21 | Aorta | SHR | 10−11 to 10−6 M | Vasodilation in presence of AT1R blocker | 14 |
C21 | Mesenteric artery | Mouse | 10−10 to 10−6 M | Vasodilation in presence of AT1R blocker | 14 |
C21 | Aorta | Mouse | 10−09 to 10−6 M | Vasodilation in absence of AT1R blocker | 14 |
C21 | Coronary microartery | Human | 10−06 to 10−4 M | Vasodilation in absence of AT1R blocker | 15 |
C21 | Iliac artery | Wistar rat | 10−07 to 10−4 M | Vasodilation in absence of AT1R blocker | 15 |
C21 | Mesenteric artery | Wistar rat | 10−07 to 10−4 M | Vasodilation in absence of AT1R blocker | 15 |
C21 | Mesenteric artery | SHR | 10−08 to 10−4 M | Vasodilation in absence of AT1R blocker | 15 |
C21 | Iliac artery | Wistar rat | 10−10 to 10−4 M | No effect | 15 |
C21 | Iliac artery | SHR | 10−05 to 10−4 M | Vasoconstriction | 15 |
C21 | Iliac artery | Mouse | 10−07 to 10−4 M | Vasodilation in absence of AT1R blocker | 15 |
C21 | Iliac artery | AT2-KO | 10−07 to 10−4 M | Vasodilation in absence of AT1R blocker | 15 |
C21 | Coronary arteries | Wistar rat | 10−04 to 10−3 M | Initial inhibition of coronary flow | 15 |
C21 | Coronary arteries | Wistar rat | 10−3 M | Increase in coronary flow | 15 |
C21 | Coronary arteries | SHR | 10−05 to 10−3 M | Initial inhibition of coronary flow | 15 |
C21 | Coronary arteries | SHR | 10−04 to 10−3 M | Increase in coronary flow | 15 |
C21 | Coronary arteries | Mouse (wild-type and AT2-KO) | 10−10 to 10−3 M | No effect | 15 |
C21 | Mesenteric arteries | SHR | 10−10 to 10−5 M | Vasodilation in presence of AT1R blocker | 32 |
Abbreviations: AT2R, angiotensin type 2 receptor; KO, knockout; SHR, spontaneously hypertensive rats; AT1R, angiotensin type 1 receptor.