Table 1.

Effects of new AT2R agonists on vascular tone ex vivo

AT2 agonist	Type of vessel	Species	Effective concentration	Result	Reference
β-substituted Ang peptides	Aorta	Mouse	10−12 to 10−6 M	Vasodilation in presence of AT1R blocker	8
β-substituted Ang peptides	Aorta	Mouse	10−12 to 10−6 M	Vasodilation in absence of AT1R blocker	8
C21	Aorta	Mouse	10−10 to 10−6 M	Vasodilation in presence of AT1R blocker	14
C21	Aorta	SHR	10−11 to 10−6 M	Vasodilation in presence of AT1R blocker	14
C21	Mesenteric artery	Mouse	10−10 to 10−6 M	Vasodilation in presence of AT1R blocker	14
C21	Aorta	Mouse	10−09 to 10−6 M	Vasodilation in absence of AT1R blocker	14
C21	Coronary microartery	Human	10−06 to 10−4 M	Vasodilation in absence of AT1R blocker	15
C21	Iliac artery	Wistar rat	10−07 to 10−4 M	Vasodilation in absence of AT1R blocker	15
C21	Mesenteric artery	Wistar rat	10−07 to 10−4 M	Vasodilation in absence of AT1R blocker	15
C21	Mesenteric artery	SHR	10−08 to 10−4 M	Vasodilation in absence of AT1R blocker	15
C21	Iliac artery	Wistar rat	10−10 to 10−4 M	No effect	15
C21	Iliac artery	SHR	10−05 to 10−4 M	Vasoconstriction	15
C21	Iliac artery	Mouse	10−07 to 10−4 M	Vasodilation in absence of AT1R blocker	15
C21	Iliac artery	AT2-KO	10−07 to 10−4 M	Vasodilation in absence of AT1R blocker	15
C21	Coronary arteries	Wistar rat	10−04 to 10−3 M	Initial inhibition of coronary flow	15
C21	Coronary arteries	Wistar rat	10−3 M	Increase in coronary flow	15
C21	Coronary arteries	SHR	10−05 to 10−3 M	Initial inhibition of coronary flow	15
C21	Coronary arteries	SHR	10−04 to 10−3 M	Increase in coronary flow	15
C21	Coronary arteries	Mouse (wild-type and AT2-KO)	10−10 to 10−3 M	No effect	15
C21	Mesenteric arteries	SHR	10−10 to 10−5 M	Vasodilation in presence of AT1R blocker	32

Abbreviations: AT2R, angiotensin type 2 receptor; KO, knockout; SHR, spontaneously hypertensive rats; AT1R, angiotensin type 1 receptor.