Table 3.

Effects of new AT2R agonists on vascular remodeling

AT2 agonist	Species/model	Dosage	Result	Reference
C21	L-NAME-induced hypertension	0.3 mg/kg BW IP	Reduced aortic wall thickness and collagen content; lowered pulse wave velocity	31
C21	SHR	1 mg/kg BW PO	Reduced mesenteric artery stiffness; reduced aortic collagen and fibronectin content; lowered oxidative stress	32

Abbreviations: AT2R, angiotensin type 2 receptor; BW, body weight; IP, intraperitoneally; L-NAME, Nω-nitro-L-arginine methyl ester hydrochloride; PO, orally; SHR, spontaneously hypertensive rats.