Table 4.
AT2 agonist | Species/strain | Dosage | Result | Reference |
---|---|---|---|---|
C21 | Sprague Dawley rats | 100–300 ng/kg/min IV | Natriuresis, GFR unchanged | 22 |
C21 | Obese Zucker rats | 5 μg/kg/min IV | Natriuresis, GFR unchanged | 23 |
C21 | 2K1C hypertension | 0.3 mg/kg BW IP | Attenuated renal inflammation | 39 |
C21 | SHR-SP | 10 mg/kg/day in 0.5% carboxymethyl-cellulose | Attenuation of albuminuria | 40 |
C21 | SHR-SP | 10 mg/kg/day in 0.5% carboxymethyl-cellulose | Attenuated renal fibrosis and inflammation | 40 |
C21 | Obese Zucker rats | 300 μg/kg/day IP | Attenuated renal inflammation | 61 |
Abbreviations: 2K1C, two-kidney, one-clip rat model; AT2R, angiotensin type 2 receptor; BW, body weight; GFR, glomerular filtration rate; IP, intraperitoneally; IV, intravenously; SHR, spontaneously hypertensive rats; SP, stroke-prone.