Table 4.

Effects of new AT2R agonists on kidney function and pathology

AT2 agonist	Species/strain	Dosage	Result	Reference
C21	Sprague Dawley rats	100–300 ng/kg/min IV	Natriuresis, GFR unchanged	22
C21	Obese Zucker rats	5 μg/kg/min IV	Natriuresis, GFR unchanged	23
C21	2K1C hypertension	0.3 mg/kg BW IP	Attenuated renal inflammation	39
C21	SHR-SP	10 mg/kg/day in 0.5% carboxymethyl-cellulose	Attenuation of albuminuria	40
C21	SHR-SP	10 mg/kg/day in 0.5% carboxymethyl-cellulose	Attenuated renal fibrosis and inflammation	40
C21	Obese Zucker rats	300 μg/kg/day IP	Attenuated renal inflammation	61

Abbreviations: 2K1C, two-kidney, one-clip rat model; AT2R, angiotensin type 2 receptor; BW, body weight; GFR, glomerular filtration rate; IP, intraperitoneally; IV, intravenously; SHR, spontaneously hypertensive rats; SP, stroke-prone.