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. 2004 Mar 23;101(14):5105–5110. doi: 10.1073/pnas.0304823101

Fig. 5.

Fig. 5.

(A) WT organotypic hippocampal cultures were incubated with the indicated concentrations of galanin and AR-M1896 during treatment with 100 nM staurosporine. Galanin significantly reduced staurosporine-induced cell death. Each point represents the mean ± SEM. n = 4; **, P < 0.01. (B) WT organotypic hippocampal cultures were incubated with the indicated concentrations of galanin during treatment with 4 mM l-glutamic acid. Galanin significantly reduced glutamate-induced cell death over the range 10 nM-1 μM. Each point represents the mean ± SEM. n = 4; *, P < 0.05; **, P < 0.01. (C) Dispersed primary hippocampal neurons were incubated with the indicated concentrations of galanin or AR-M1896 during treatment with staurosporine. AR-M1896 and galanin significantly reduced staurosporine-induced cell death in WT cultures. Each point represents the mean ± SEM (n = 4). n = 3; **, P < 0.01.